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Holmes Lab at UC Irvine

Publications

Shown are select publications. A full list of publications on Todd Holmes Google Scholar can be found here.

Nocturnal mosquito Cryptochrome1 mediates greater electrophysiological
and behavioral responses to blue light relative to diurnal mosquito
Cryptochrome Todd C. Holmes , David Au, Jenny C. Liu, Thanh H. Nguyen, Alexander J. Foden, Soo J. Park, Mia Dimalanta and Zhaoxia Yu (2022) Frontiers in Neuroscience, In Press.

David D.Au, Alexander J.Foden, Soo JeePark Thanh H.Nguyen, Jenny C.Liu Mary D.Tran,Olga G.Jaime, ZhaoxiaYu, Todd C.Holmes. (2022) Mosquito cryptochromes expressed in Drosophila confer species-specific behavioral light responses. Current Biology.

Yu, Z., Guindani, M., Grieco, S.F., Chen, L., Holmes, T.C., and Xu, X.
(2021) Beyond t-Test and ANOVA: applications of mixed-effects models for
more rigorous statistical analysis in neuroscience research. Neuron. Nov
9. ScienceDirect.

Nave, C., Roberts, L., Hwu, P., Estrella, J.D., Vo, T.C., Nguyen, T.H.,
Bui, T.T., Rindner, D.J., Pervolarakis, N., Shaw, P.J., Leise, T.L., and
Holmes, T.C. (2021) Weekend light shifts evoke persistent Drosophila
circadian neural network desynchrony. J. Neuroscience. 2021 Jun
16. JNeurosci.

Grieco, S.F., Qiao, X., Johnston, K.G., Chen, L., Nelson, R.R., Lai, C.,
Holmes, T.C., and
Xu, X. (2021) Neuregulin signaling mediates the acute and sustained
antidepressant effects of subanesthetic ketamine. Translational
Psychiatry. 2021 Feb 24. Nature.

Ravenscroft, T.A., Janssens, J., Lee, P.-T., Tepe, B., Marcogliese,
P.C., Makhzami, S., Holmes, T.C., Aerts, S. and Bellen, H.J. (2020)
Drosophila voltage-gated sodium channels are only expressed in active
neurons and are localized to distal axonal initial segment-like domains.
J. Neuroscience, Sep 14.

Xu, X., Holmes, T.C., Luo, M.-H., Beier, K.T., Horwitz, G.D., Zhao, F.,
Zeng, W., Hui, M., Semler, B.L. and Sandri-Golden, R.M. (2020) Viral
Vectors for Neural Circuit Mapping and Recent Advances in Trans-synaptic
Anterograde Tracers. Neuron, Jul 31. ScienceDirect.

Grieco, S.F., Qiao, X., Zheng, X., Liu, Y., Chen. L., Zhang, H., Yu, Z.,
Gavornik, J., Lai, C., Gandhi, S., Holmes, T.C., and Xu, X. (2020)
Subanesthetic ketamine reactivates adult cortical plasticity to restore
vision from amblyopia. Current Biology, 2020 Sep 21. ScienceDirect.

Baik, L.S., Nave, C., Au, D.D., Guda, T., Chevez, J.A., Ray, A. and
Holmes, T.C. (2020) Circadian Regulation of Light-Evoked Attraction and
Avoidance Behaviors in Daytime- versus Nighttime-Biting Mosquitoes.
Current Biology, Jun 28. PNAS

Baik, L.S., Au, D., Nave, C., Foden, A.J. Enrriquez-Villalva, W.K. and
Holmes, T.C. (2019) Distinct mechanisms of Drosophila
CRYPTOCHROME-mediated light-evoked membrane depolarization and in vivo
clock resetting. Proc Natl Acad Sci U S A. 116(46):23339-23344. Epub
2019 Oct 28. PNAS.

Sun, Y., Jin, S., Lin, X., Chen, L., Qiao, X., Jiang, L., Zhou, P.,
Johnston, K.G., Golshani, P., Nie, Q., Holmes, T.C., Nitz, D.A. and Xu,
X. (2019) CA1-Projecting Subiculum Neurons Facilitate Object-Place
Learning. Nature Neuroscience. 22(11):1857-1870. Epub 2019 Sep 23. Nature.

Baik, L.S., Recinos, Y., Chevez, J.A., Au, D.A. and Holmes, T.C. (2019)
Multiple phototransduction inputs integrate to mediate UV light-evoked
avoidance/attraction behavior in Drosophila. J. Biological Rhythms.
Aug; 34(4):391-400. Epub 2019 May 29. Sagepub.

Baik LS., Recinos Y, Chevez JA., Holmes TC. “Circadian modulation of light-evoked avoidance/attraction behavior in Drosophila.” PLOS ONE 13, no. 8 (2018).

Sun Y, Nitz DA, Holmes TC, and Xu X. “Opposing and Complementary Topographic Connectivity Gradients Revealed by Quantitative Analysis of Canonical and Noncanonical Hippocampal CA1 Inputs.” eNeuro 5, no. 1 (2018): ENEURO.NIH.

Ni,JD., Baik,LS., Holmes TC, and Montell C. “A rhodopsin in the brain functions in circadian photoentrainment in Drosophila.” Nature 545, no. 7654 (2017): Nature.

Sun Y, Grieco SF., Holmes TC, and Xu X. “Local and Long-Range Circuit Connections to Hilar Mossy Cells in the Dentate Gyrus.” eNeuro 4, no. 2 (2017): ENEURO. NIH.

Baik, LS., Fogle KJ, Roberts L, Galschiodt AM, Chevez JA, Recinos Y, Nguy V, and Holmes TC. “CRYPTOCHROME mediates behavioral executive choice in response to UV light.” Proceedings of the National Academy of Sciences 114, no. 4 (2017): PNAS.

Barber AF, Erion R, Holmes TC, Sehgal A. “Circadian and feeding cues integrate to drive rhythms of physiology in Drosophila insulin-producing cells.” Genes Dev. 30, no. 23 (2016): CSH Press.

Sun Y, Ikrar T, Davis MF, Gong N, Zheng X, Luo ZD, Lai C, Mei L, Holmes TC, Gandhi SP, Xu X. “Neuregulin-1/ErbB4 Signaling Regulates Visual Cortical Plasticity.” Neuron. 92, no. 1 (2016): ScienceDirect.

Roberts L, Leise TL, Welsh DK, Holmes TC. “Functional Contributions of Strong and Weak Cellular Oscillators to Synchrony and Light-shifted Phase Dynamics.” J Biol Rhythms. 31, no. 4 (2016): Sagepub.

Xu X, Sun Y, Holmes TC, López AJ. “Noncanonical connections between the subiculum and hippocampal CA1.” J Comp Neurol. 524, no 17 (2016) : Wiley.

Xu X, Ikrar T, Sun Y, Santos R, Holmes TC, Francesconi W, and Berton F. “High-resolution and cell-type-specific photostimulation mapping shows weak excitatory vs. strong inhibitory inputs in the bed nucleus of the stria terminalis.” J Neurophysiol. 115, no. 6 (2016): Physiology.

Das A, Holmes TC, and Sheeba V. “dTRPA1 in Non-circadian Neurons Modulates Temperature-dependent Rhythmic Activity in Drosophila melanogaster.” J Biol Rhythms. 31, no. 3 (2016): Sagepub.

Roberts L, Leise TL, Noguchi T, Galschiodt AM, Houl JH, Welsh DK, and Holmes TC. “Light evokes rapid circadian network oscillator desynchrony followed by gradual phase retuning of synchrony.” Curr Biol. 25, no. 7 (2015): ScienceDirect.

Fogle, Keri J., Lisa S. Baik, Jerry H. Houl, Tri T. Tran, Logan Roberts, Nicole A. Dahm, Yu Cao, Ming Zhou, and Todd C. Holmes. “CRYPTOCHROME-mediated phototransduction by modulation of the potassium ion channel β-subunit redox sensor.” Proceedings of the National Academy of Sciences 112, no. 7 (2015): PNAS.

Helfrich-Förster C, Nitabach MN, and Holmes TC. “Insect Circadian Clock Outputs.” Essays Biochem. 49, no.1 (2011): Portland Press.

Fogle KJ, Parson KG, Dahm NA, and Holmes TC. “CRYPTOCHROME is a blue-light sensor that regulates neuronal firing rate.” Science. 331, no. 6023 (2011)

Sheeba V, Fogle KJ, and Holmes TC. “Persistence of morning anticipation behavior and high amplitude morning startle response following functional loss of small ventral lateral neurons in Drosophila.” PLoS One. 5, no. 7 (2011): PLOS.

Sheeba V, Fogle KJ, Kaneko M, Rashid S, Chou YT, Sharma VK, and Holmes TC “.Large ventral lateral neurons modulate arousal and sleep in Drosophila.” Curr Biol. 18, no. 20 (2008): ScienceDirect.

Ayaz D, Leyssen M, Koch M, Yan J, Srahna M, Sheeba V, Fogle KJ, Holmes TC, and Hassan BA. “Axonal injury and regeneration in the adult brain of Drosophila.” J Neurosci. 28, no. 23 (2008)

Sheeba V, Kaneko M, Sharma VK, Holmes TC. “The Drosophila circadian pacemaker circuit: Pas De Deux or Tarantella?” Crit Rev Biochem Mol Biol. 43, no. 1 (2008): Taylor & Francis Online.

Sheeba V, Sharma VK, Gu H, Chou YT, O’Dowd DK, and Holmes TC. “Pigment dispersing factor-dependent and -independent circadian locomotor behavioral rhythms. J Neurosci. 28, no. 1 (2008).

Sheeba V, Gu H, Sharma VK, O’Dowd DK, and Holmes TC. “Circadian- and light-dependent regulation of resting membrane potential and spontaneous action potential firing of Drosophila circadian pacemaker neurons.” J Neurophysiol. 99, no. 2 (2008): Physiology.

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